![]() ![]() ![]() The pharmacokinetics of this drug are not significantly affected by renal failure (CrCl under 10 mL/min).Use(s): Reversal of conscious sedation induced with benzodiazepines Renal Dose Adjustments Safety and efficacy of repeated administration for resedation in pediatric patients has not been established.Resedation occurred in 7 of 60 pediatric patients who were fully alert 10 minutes after starting this medication.About half of the patients required the maximum 5 doses.Mean total dose in pediatric clinical trials was 0.65 mg (range 0.08 to 1 mg).Maximum dose: 0.05 mg/kg or 1 mg, whichever is lower If desired level of consciousness is not achieved after an additional 45 seconds, a second 0.01 mg/kg dose may be given and repeated at 60 second intervals, if needed, up to a maximum of 4 doses.Initial dose: 0.01 mg/kg IV over 15 seconds Use(s): Management of benzodiazepine overdose Usual Pediatric Dose for Reversal of Sedation If a patient has not responded 5 minutes after receiving a cumulative dose of 5 mg, the major cause of sedation is unlikely to be benzodiazepines and additional doses of this drug are unlikely to help.On rare occasions, patients who partially respond to 3 mg may require additional titration up to a total dose of 5 mg, given in the same manner as above.Doses beyond 3 mg do not reliably produce additional effects.Most patients with a benzodiazepine overdose will respond to a cumulative dose of 1 to 3 mg.Patients should have secure airway and venous access before administration, and be awakened gradually.Resedation: Repeated doses may be given at 20 minute intervals as needed ![]() Further doses of 0.5 mg over 30 seconds may be given at 1 minute intervals, if needed.If desired level of consciousness is not achieved after waiting 30 seconds, a second dose of 0.3 mg may be given over another 30 seconds.Usual Adult Dose for Benzodiazepine Overdose Use(s): Complete or partial reversal of the sedative effects of benzodiazepines where general anesthesia has been induced and/or maintained with benzodiazepines, or where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Administer as a series of small injections as described to control reversal of sedation to desired endpoint and minimize adverse effects.Most patients respond to doses of 0.6 to 1 mg.Individualize dose based on patient response.Maximum dose: 1 mg total at any one time no more than 3 mg in any one hour Resedation: 0.2 mg every 20 minutes as needed Repeated doses: 0.2 mg may be given every minute until the desired level of consciousness is achieved. Initial dose: 0.2 mg IV one time over 15 seconds. Usual Adult Dose for Reversal of Sedation ![]()
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